I often hear that people who are taking antibiotics experience wild fluctuations between feeling full of energy and completely alert but soon after feeling impossibly fatigued and sick.
Does this have anything to do with the antibiotics being used by the body as anything? For example as a hormone or as a source of nutrition? Is this this a reported side effect when used for other infections?
I have never heard about this phenomenon from my patients or professors at the Medical School, but this is a possible mechanism that comes to my mind.
One of the classification for antibiotics takes consideration the effect on bacteria. Two possible effects are either stopping the proliferation (and letting the immune system to kill those that are currently present in the body) or killing bacteria directly.
The second approach is obviously more effective but has one big disadvantage: massive death of bacteria leads to the massive release of their toxins that are normally trapped within they bodies (so-called endotoxins). The symptoms you describe as "impossible fatigue" match exactly the symptoms of bacterial intoxication -- and this can increase upon the antibiotics intake.
Depending upon the bioavailability and pharmacokinetics some antibiotics might not kill all bacteria "on the first run" and the symptoms of intoxication recur several times with decreasing severity of manifestations.
"There are antibiotics which contain carbohydrates, such as Gentamycin and Streptomycin (the aminoglycosides). These must be the antibiotics that could account for this phenomenon."
My conjecture that the carbohydrate moities contained within aminoglycosides account for the high energy is incorrect. Aminoglycosides are NEVER metabolized by the body, they are excreted out into the urine UNCHANGED. See here: http://www.ebmedicine.net/topics.php?paction=showTopicSeg&topic_id=43&seg_id=839
And even if it were possible to metabolize the carbohydrate molecules within them, the energy released would be far less than the energy consumed to break their linkages in the first place, thus placing a negative energy balance on the body, and thus, not providing the burst of energy that is apparently observed after taking antibiotics.
- Amoxicillin is an antibiotic that kills bacteria by inhibiting the synthesis of cell wall mucopeptides (crystal lattice-like structures composed of amino acids that make up the cell wall). This weakens and destroys the bacterial cell wall.
- Amoxicillin has a similar action to ampicillin.
- Amoxicillin belongs to the group of medicines known as penicillins.
- Active against bacteria that commonly cause ear, nose, or throat infections.
- May also be used to treat infections of the genitourinary tract, skin, or lower respiratory tract caused by susceptible bacteria.
- Specifically active against:
- Aerobic gram-positive bacteria: Enterococcus faecalis, Staphylococcus species (beta-lactamase negative strains only), certain strains of Streptococcus species including S. pneumoniae
- Aerobic gram-negative bacteria (beta-lactamase negative strains only): Escherichia coli, Haemophilus influenzae, Neisseria gonorrhoeae, Proteus mirabilis.
- Also has activity against Helicobacter pylori, a bacteria often associated with stomach ulcers. Amoxicillin, when used in combination with other medicines (such as lansoprazole and clarithromycin), can help reduce the risk of duodenal ulcer recurrence.
- Usually well-tolerated.
- Generic amoxicillin is available.
What Are The Pros And Cons Of Taking Antibiotics?
Antibiotics are powerful drugs that help our bodies ward off diseases caused by bacteria. When used appropriately, they quickly and effectively eliminate infections, causing us to feel better in a matter of days. However, when used to treat other health conditions, antibiotics are not only ineffective but can be harmful to our overall health.
According to a growing body of research , the more we take antibiotics to cure bacterial infections, the more our bodies build resistance, which wipes out their effectiveness in making us well.
How do you know when they will work?
Antibiotics fight bacteria that cause strep throat and ear , sinus and urinary infections. They do not work for the flu, colds, coughs and sore throats . Consult with your doctor about your symptoms, which can help determine the origin of your illness. Ask your doctor about the benefits and drawbacks of taking antibiotics for your diagnosis.
Following are a few pros and cons of taking antibiotics:
Pros of taking antibiotics
· Antibiotics can slow the growth of and kill many types of infection.
· In some cases, such as before surgery, antibiotics can prevent infection from occurring.
· Antibiotics are fast-acting some will begin working within a few hours.
· They are easy to take: Most antibiotics are oral medications. Your doctor may decide to give you an injection if it is imperative that the medicine gets into your system quickly.
Cons of taking antibiotics
· If you take antibiotics often, your body can build a resistance to antibiotic drugs, which could cause antibiotics to become less effective.
· The longer course of treatment for an antibiotic, the more damage can be done to the body’s immune system.
· Some antibiotics can have side effects, from digestive issues to bone damage to sensitivity to sunlight. Make sure to read the fine print that comes with your medicine so that you know the risks.
“Inappropriate use of antibiotics is creating a huge threat to the health of our communities,” says Jennifer Rose Boozer , DO, clinical assistant professor of family medicine at the Keck School of Medicine of USC. By taking antibiotics when we do not need them we increase the chances of bacteria becoming resistant to the medication and then when we really need it those antibiotics will not be effective. This can lead to an increase in hospitalizations, due to the need for IV antibiotics, or even increased chances of death.”
“It is important that you protect yourself and your family by only taking antibiotics that are prescribed to you when your doctor advises you to do so,” expresses Dr. Boozer, who is also a family medicine physician at Keck Medicine of USC – Glendale and Pasadena . “Sharing antibiotics or taking leftover medications from a previous illness is never advised.”
This question originally appeared on Quora - the place to gain and share knowledge, empowering people to learn from others and better understand the world. You can follow Quora on Twitter, Facebook, and Google+. More questions:
Incorporate a Healthy Diet
Following a poor diet can decrease your stamina, by raising inflammation in your body and increasing levels of fat. Consuming candy, baked sweets, soda and other sugary treats causes blood sugar level fluctuations and energy crashes. Eating a large heavy meal makes your body focus on digestion so you feel sleepy, not peppy.
Eating more than your body needs can diminish your stamina, but so can shortchanging yourself on calories. It leaves your body without the necessary fuel to convert to energy.
Increase your stamina by eating five to six small meals each day and stick to fruits, vegetables, lean meats, fish, legumes and whole grains for high-quality, high-energy fuel, according to Mayo Clinic.
For best results, consult a dietitian to determine how many calories you need to maintain a healthy weight and activity level. In time, your nutritious diet will boost your stamina.
Do Muscle Fibers Play A Role In Training For Strength And Endurance?
Yes, this is actually an important aspect of successfully training for the discipline you are involved in. Muscle fibers are generally classified into one of two types, namely type I, also known as slow twitch, and type II, referred to as fast twitch.
Fast Twitch Muscle Fibers (Type II)
When we perform an activity, the body almost always recruits fast twitch muscle fibers first. These types of muscle fibers allow for explosive movement, which is why when fresh into an exercise or activity you are able to perform it much more easily, than compared to several minutes later.
Their explosive nature can be attributed to their ability to generate the maximum amount of force and rapidly contract, depending heavily on stored muscle glycogen (stored form of glucose) to do this. If you are desirous of testing the limits of your Type II muscle fibers in the quest for hypertrophy, short burst intense exercise is the way to go. This fiber type also translates most significantly to your overall stamina levels.
A good analogy of the way they work is to think of the nitrous you have probably seen equipped to cars in the Fast and Furious movies. They are capable of yielding massive bursts of speed and power, cannot be used frequently and are rapidly depleted of their energy source.
Strength training, including weightlifting and sprints assist with training of fast twitch muscle fibers, in turn improving your stamina. Fast twitch muscle fibers primarily use glucose as an energy source (glycolytic energy production), though specific subtypes can also make use of small amounts of fatty acids for fuel.
Slow Twitch Muscle Fibers (Type I)
Slow twitch muscle fibers are in for the long game, usually recruited a few minutes after activity has begun and your fast twitch muscle fibers have begun to fatigue. Slow twitch muscle fibers do not possess the explosive potential of the other type, which is why you just can’t seem to move the same loaded bar with the same speed, number of repetitions or fail to move it altogether a few sets into your workout, or if attempting several sprint cycles.
Slow twitch muscle fibers do not require as much energy per second compared to fast twitch muscle fibers, and are a sort of “energy saving” maintenance muscle. They will allow you to perform at a lower intensity for an extended period of time before becoming fatigued. Slow twitch muscle fibers are also very efficient at using fat for fuel (oxidative energy production)
On another note, fast twitch muscle fibers are the ones that yield hypertrophic growth (owing to their larger cell diameter), which is why bodybuilders, Olympic sprinters and other strength athletes are capable of building big muscular bodies, while endurance athletes have longer, slender muscle heads (with smaller individual diameters). Slow twitch muscle fibers are also recruited involuntarily and unconsciously throughout most of our waking hours, to accomplish tasks such as walking or even maintaining posture. This also explains why they are highly resistant to fatigue, or your body would take a beating from staying upright or even casual walking.
The top 3 energy supplements on sale today
We will now take you through the 3 best pre-made energy supplements currently on the market.
Over the years we have seen a lot of energy supplements come and go.
Hundreds of energy supplements have come onto the scene promising amazing results, but the vast majority end up disappearing when people figure out that they just don’t deliver.
We’ve seen lots of stacks which claim to naturally boost energy, but in reality they use dangerous synthetic stimulants to increase energy levels.
The best energy supplements deliver increased energy levels, and they do so without causing side effects, health issues, or dependency.
We apply a very strict method when judging supplements, including supplements for energy.
For something to appear on our list of the best energy supplements, it needs to meet the following criteria:
- Ingredients are backed by hard, publicly available, peer-reviewed clinical trials
- None of the ingredients can be known to cause serious side effects or dependency
- Quality of the product must represent superb value for money – no fillers, no bogus substances, no low-grade ingredients
So, with that in mind, we’ve compiled a list of the best supplements for energy on the market today. These supplements are all excellent for promoting energy and focus, and they all represent great value for money. They have individual strengths take the time to read about them and see which is the right energy supplement for you.
#1 Supplement for energy and focus – Performance Lab Stim + Energy
If your goal is higher energy levels, improved focus, and better cognitive performance, then this is the supplement stack for you.
Performance Lab Stim delivers a 50mg dose of natural caffeine combined with 100mg of Suntheanine. This results in a cleaner, sharper, longer caffeine buzz with fewer side effects.
The caffeine and theanine is supported by Tyrosine, which has been shown to improve cognitive performance in people with sleep deprivation. All this is capped off with a B vitamin complex to support energy metabolism and neurotransmitter production.
Performance Lab Energy works in a very different, but complimentary way, to Stim. It is designed to optimize and protect your cell mitochondria, enhance energy metabolism, and reduce oxidative stress. This is a daily, long-term energy supplement for people fighting chronic fatigue.
The benefits of using Performance Lab Stim and Energy together are extensive. They include:
- Enhanced mitochondria for lasting energy
- More efficient energy metabolism
- Rapid increase in mental and physical energy levels
- Reduced fatigue
- Heightened focus
- Enhanced cognitive function
Performance Lab have completely dominated the market with their brand new range of energy supplements. The company focuses exclusively on high quality, pure ingredients, and simple, easy stackable formulas. This “stackability” is a major selling point for people with very particular needs.
The combination of Performance Lab Energy and Stim is – in our opinion – an unbeatable stack for increasing energy levels, heightening focus, decreasing fatigue, and enhancing cognitive performance. The two supplements are purposefully designed to work together: Stim can serve as a ‘as and when’ energy booster while Energy can serve as a daily fatigue-fighter. Two fantastic energy supplements together make for one powerful stack.
Learn more about Performance Lab Stim.
Learn more about Performance Lab Energy.
#2 – Runner-up – Qualia Nootropic Energy
Qualia Nootropic Energy is a brand new energy supplement from Neurohacker Collective. It is designed to be an all-in-one, complete energy supplement. Qualia Nootropic Energy delivers nootropics for enhanced cognition, stimulants for higher energy levels, as well as a range of herbs and amino acids for reduced stress, greater focus, and reduced oxidative stress.
After reviewing the formula, we think this energy booster is definitely going increase energy levels. Qualia Nootropic Focus also looks capable of significantly improving focus, information processing, reaction times, and so on.
However, there are some big problems with this energy supplement. The main reason why it is not our top rated energy supplement is the price tag – Qualia Nootropic Focus is $99.00 per month. The first bottle is $59.50, but that price is conditional on you signing up for a subscription. Despite its many strengths, this energy stack is not worth $100 a month!
There is also a bit too much caffeine in the formula for our liking. The 90mg of caffeine you get in this energy booster is more than you get form a single espresso. We much prefer Performance Lab’s setup, where you can take Stim on top of the Energy stack as and when you need a boost.
At the end of the day though, this is still a great energy supplement. It is listed as one of the best energy supplements for some very good reasons:
- Provides a good dose of Caffeine
- Delivers lots of Tyrosine
- Big dose of Alpha-GPC for cognition
But it is not the best energy booster for a few very important reasons:
- No B vitamins
- Caffeine should not be used every day
- Many users wont want Alpha-GPC every day
Neurohacker Collective is one of the leading brands in the nootropics industry. These guys burst onto the scene with Qualia, which was a single nootropic stack. They have since launched individual nootropics with more precise functions – Qualia Mind and Qualia Focus. These are good quality supplements for sure Qualia Mind is effective for enhancing short-term cognitive performance, while Qualia Focus looks like it will support brain health and functionality over the long term.
However, Neurohacker Collective do have a major problem with pricing – all of their products are super expensive! Qualia Nootropic Focus is exactly the same. In our opinion, $99 a month is just too much. Compared to Performance Lab Stim ($35) and Performance Lab Energy ($50), it just doesn’t make sense!
Antibiotic drug–target interactions, and their respective direct effects, are generally well characterized. By contrast, the bacterial responses to antibiotic drug treatments that contribute to cell death are not as well understood and have proven to be complex as they involve many genetic and biochemical pathways. In this Review, we discuss the multilayered effects of drug–target interactions, including the essential cellular processes that are inhibited by bactericidal antibiotics and the associated cellular response mechanisms that contribute to killing. We also discuss new insights into these mechanisms that have been revealed through the study of biological networks, and describe how these insights, together with related developments in synthetic biology, could be exploited to create new antibacterial therapies.
Antibiotic use linked to greater risk of heart attack and stroke in women
Women who take antibiotics over a long period of time are at increased risk of heart attack or stroke, according to research carried out in nearly 36,500 women.
The study, published in the European Heart Journal  today (Thursday), found that women aged 60 or older who took antibiotics for two months or more had the greatest risk of cardiovascular disease, but long duration of antibiotic use was also associated with an increased risk if taken during middle age (aged 40-59). The researchers could find no increased risk from antibiotic use by younger adults aged between 20-39.
Professor Lu Qi, director of the Tulane University Obesity Research Centre, Tulane University, New Orleans, and adjunct professor of nutrition at Harvard T.C. Chan School of Public Health, Boston, USA, who led the research, says that a possible reason why antibiotic use is linked to an increased risk of cardiovascular disease is because antibiotics alter the balance of the micro-environment in the gut, destroying "good" probiotic bacteria and increasing the prevalence of viruses, bacteria or other micro-organisms that can cause disease.
"Antibiotic use is the most critical factor in altering the balance of microorganisms in the gut. Previous studies have shown a link between alterations in the microbiotic environment of the gut and inflammation and narrowing of the blood vessels, stroke and heart disease," he said.
The researchers studied 36,429 women who took part in the Nurses' Health Study, which has been running in the USA since 1976. The current study looked at data from 2004 to June 2012. In 2004 the women were aged 60 or older, and they were asked about their use of antibiotics when they were young (20-39), middle-aged (40-59) or older (60 and older). The researchers categorised them into four groups: those who had never taken antibiotics, those who had taken them for time periods of less than 15 days, 15 days to two months, or for two months or longer.
During an average follow-up period of nearly eight years, during which time the women continued to complete questionnaires every two years, 1056 participants developed cardiovascular disease.
After adjustments to take account of factors that could affect their results, such as age, race, sex, diet and lifestyle, reasons for antibiotic use, overweight or obesity, other diseases and medication use, the researchers found that women who used antibiotics for periods of two months or longer in late adulthood were 32% more likely to develop cardiovascular disease than women who did not use antibiotics. Women who took antibiotics for longer than two months in middle age had a 28% increased risk compared to women who did not.
These findings mean that among women who take antibiotics for two months or more in late adulthood, six women per 1,000 would develop a cardiovascular disease, compared to three per 1,000 among women who had not taken antibiotics.
The first author of the study is Dr Yoriko Heianza. a research fellow at Tulane University. She said: "By investigating the duration of antibiotic use in various stages of adulthood we have found an association between long-term use in middle age and later life and an increased risk of stroke and heart disease during the following eight years. As these women grew older they were more likely to need more antibiotics, and sometimes for longer periods of time, which suggests a cumulative effect may be the reason for the stronger link in older age between antibiotic use and cardiovascular disease."
The most common reasons for antibiotic use were respiratory infections, urinary tract infections and dental problems.
The study is the largest prospective study to investigate the link between antibiotic use and risk of heart disease and stroke, and this is one of the strengths of the study, as well as the long follow-up and comprehensive information on factors that could affect the results such as life style, diet, age, other diseases and medication use.
Limitations include the fact that the participants reported their use of antibiotics and so this could be mis-remembered. However, as they were all health professionals, they were able to provide more accurate information on medication use than the general population. The researchers did not have information on the different classes of antibiotics used, but believe that the most common type of prescription tends to depend on the infections it is treating, and information on these was included in their analysis. As the study only looked at middle-aged and elderly women, the results cannot necessarily be extrapolated to younger ages and to men.
Prof Qi concluded: "This is an observational study and so it cannot show that antibiotics cause heart disease and stroke, only that there is a link between them. It's possible that women who reported more antibiotic use might be sicker in other ways that we were unable to measure, or there may be other factors that could affect the results that we have not been able take account of.
"Our study suggests that antibiotics should be used only when they are absolutely needed. Considering the potentially cumulative adverse effects, the shorter time of antibiotic use the better."
New information about bacterial enzymes to help scientists develop more effective antibiotics, cancer drugs
Scientists studying the biosynthesis and production of microbial natural products now have a greater insight into the process thanks to research conducted at the U.S. Department of Energy’s Argonne National Laboratory in collaboration with scientists from the Scripps Research Institute and Rice University.
Armed with this new information, researchers can use it to manipulate nature’s biosynthetic machinery to produce more effective antibiotics and cancer-fighting drugs.
Streptomyces are Gram-positive bacteria that live in soil. These bacteria possess a complex metabolism and are known to naturally produce clinically useful compounds. One large class of natural products, known as polyketides, includes many drugs such as erythromycin (antibacterial) and rapamycin (immunosuppressive), as well as promising drug leads such as migrastatin and oxazolomycin reported in the current study, which show important antibacterial, antitumor, and anti-human immunodeficiency virus activity.
These antibiotics are synthesized by a set of enzymes that are orchestrated into assembly-line-like biosynthetic machinery. Researchers in this study focused on understanding the enzymes specificity, which is responsible for generating the vast chemical structural diversities known for migrastatin, oxazolomycin and other polyketides.
Andrzej Joachimiak works in Argonne’s Biosciences division at Argonne and is one of the authors of a recent paper published on the topic in The Proceedings of the National Academy of Sciences of the United States of America.
“ If we understand the specificity of these processes, we will be able to engineer the enzymes to accept other chemical molecules, opening the door to new treatments for some of our most challenging diseases,” said Joachimiak, director of the Structural Biology Center, located at Argonne.
Antibiotics are made up of a set of multiple enzymes that perform consecutive actions. Scientists seek to modify these molecules chemically to create new drugs with improved therapeutic properties. “ In order to do that we need to understand the specificity of this ‘ enzymatic assembly line,’ ” Ben Shen of the Scripps Research Institute said. “ We need to know which part we need to place, and do it in a rational and specific manner, to synthesize the designer compounds.”
Manipulating enzymes that catalyze complex reactions that alter natural product structures to create diverse novel compounds with new biological activities is a key.
This work was done with the help of the Advanced Protein Characterization Facility, which has greatly aided medical and biomedical research by automating the production of protein and protein crystals — two key steps in solving the structure of proteins, understanding how they operate, and ultimately helping to identify new and more effective drug treatments.
Proteins are long molecular chains that fold on themselves in complex ways with many of those folds serving as docking sites where other molecules — including those from pathogens — can attach. In protein structure research, snippets of the DNA code for a protein are cloned. The clones are used to produce the proteins that are isolated and exposed to various chemical environments with the hope that one of them will cause the protein molecules to form a crystal. This can take days, weeks or even months. But when it happens, the protein molecules align to form a repeating array. That repetitive configuration allows X-rays from the Advanced Photon Source, a DOE Office of Science User Facility located at Argonne, to analyze the three-dimensional structure of the molecules by means of their different signatures.
This helps Joachimiak and his team to solve age-old problems. “ This work would not be possible without the technology and equipment available here at Argonne,” he said.
This research is detailed in the paper “ Structural and Evolutionary Relationships of ‘ AT-less’ Type I Polyketide Synthase Ketosynthases,” published in the Proceedings of the National Academies of Science. Additional co-authors include Jeremy R. Lohman, Ming Ma, Jerzy Osipiuk, Boguslaw Nocek, Youngchang Kim, Changsoo Chang, Marianne Cuff, Jamey Mack, Lance Bigelow, Hui Li, Michael Endres, Gyorgy Babnigg, and George N. Phillips, Jr.
This work was was supported in part by grants made available from the National Institutes of Health.
The symptoms of a yeast infection depend on where it is located in the body. The chart below shows the most common symptoms of a yeast infection. But yours may be slightly different.
Skin folds or navel
- Rash with redness and skin breakdown
- Patches that ooze clear fluid
- Itching or burning
- White or yellow discharge from the vagina
- Redness in the external area of the vagina
- Redness on the underside of the penis
- Scaling on the underside of the penis
- Painful rash on the underside of the penis
- White patches on the tongue and inside of the cheeks
- Redness or soreness
- Difficulty swallowing may mean you have yeast in your esophagus
Corners of the mouth (angular cheilitis)
- White or yellow nail that separates from the nail bed
The symptoms of a yeast infection may look like other skin conditions. Always see your healthcare provider for a diagnosis.
9 tips to boost your energy — naturally
Go to the store, and you'll see a multitude of vitamins, herbs, and other supplements touted as energy boosters. Some are even added to soft drinks and other foods. But there's little or no scientific evidence that energy boosters like ginseng, guarana, and chromium picolinate actually work. Thankfully, there are things you can do to enhance your own natural energy levels. Here are nine tips:
1. Control stress
Stress-induced emotions consume huge amounts of energy. Talking with a friend or relative, joining a support group, or seeing a psychotherapist can all help diffuse stress. Relaxation therapies like meditation, self-hypnosis, yoga, and tai chi are also effective tools for reducing stress.
2. Lighten your load
One of the main reasons for fatigue is overwork. Overwork can include professional, family, and social obligations. Try to streamline your list of "must-do" activities. Set your priorities in terms of the most important tasks. Pare down those that are less important. Consider asking for extra help at work, if necessary.
Exercise almost guarantees that you'll sleep more soundly. It also gives your cells more energy to burn and circulates oxygen. And exercising can lead to higher brain dopamine levels, which helps elevate mood. When walking, pick up the pace periodically to get extra health benefits.
4. Avoid smoking
You know smoking threatens your health. But you may not know that smoking actually siphons off your energy by causing insomnia. The nicotine in tobacco is a stimulant, so it speeds the heart rate, raises blood pressure, and stimulates brain-wave activity associated with wakefulness, making it harder to fall asleep. And once you do fall asleep, its addictive power can kick in and awaken you with cravings.
5. Restrict your sleep
If you think you may be sleep-deprived, try getting less sleep. This advice may sound odd but determining how much sleep you actually need can reduce the time you spend in bed not sleeping. This process makes it easier to fall asleep and promotes more restful sleep in the long run. Here's how to do it:
- Avoid napping during the day.
- The first night, go to bed later than normal and get just four hours of sleep.
- If you feel that you slept well during that four-hour period, add another 15–30 minutes of sleep the next night.
- As long as you're sleeping soundly the entire time you're in bed, slowly keep adding sleep on successive nights.
6. Eat for energy
Eating foods with a low glycemic index — whose sugars are absorbed slowly — may help you avoid the lag in energy that typically occurs after eating quickly absorbed sugars or refined starches. Foods with a low glycemic index include whole grains, high-fiber vegetables, nuts, and healthy oils such as olive oil. In general, high-carbohydrate foods have the highest glycemic indexes. Proteins and fats have glycemic indexes that are close to zero.
7. Use caffeine to your advantage
Caffeine does help increase alertness, so having a cup of coffee can help sharpen your mind. But to get the energizing effects of caffeine, you have to use it judiciously. It can cause insomnia, especially when consumed in large amounts or after 2 p.m.
8. Limit alcohol
One of the best hedges against the midafternoon slump is to avoid drinking alcohol at lunch. The sedative effect of alcohol is especially strong at midday. Similarly, avoid a five o'clock cocktail if you want to have energy in the evening. If you're going to drink, do so in moderation at a time when you don't mind having your energy wind down.
9. Drink water
What's the only nutrient that has been shown to enhance performance for all but the most demanding endurance activities? It's not some pricey sports drink. It's water. If your body is short of fluids, one of the first signs is a feeling of fatigue.
For more information on the many things you can do to increase your natural energy, order our Special Health Report, Boosting Your Energy.
Image: ©Gilaxia | GettyImages