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Is lysergic acid diethylamide (LSD) metabolized in the body?

Is lysergic acid diethylamide (LSD) metabolized in the body?



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Is LSD broken down into other compounds by enzymes or hormones? If so, at what point and where in the body does this happen? I researched several papers appearing in a google search, but unfortunately I did not understand most of it.


Short answer
LSD appears to be enzymatically broken down in the liver.

Background
First off, hormones do not break down anything; enzymes are the work horses that mediate metabolism.

According to a review paper (Passie et al., 2008), humans metabolize LSD into structurally similar metabolites (Fig. 1) by NADH-dependent microsomal liver enzymes to the inactive 2-oxy-LSD and 2-oxo-3-hydroxy LSD. LAE is formed through enzymatic N-dealkylation of the diethylamide radical at side chain position 8. Di-hydroxy-LSD and nor-LSD are also metabolites, as well as 2-oxo-LSD, 13- and 14-hydroxy-LSD as glucoronides, lysergic acid ethyl-2-hydroxyethylamide (LEO), and trioxylated LSD.

Note that the monoamine oxidase (MAO) system is unlikely to break down LSD. MAO are enzymes that catalyze the oxidation of monoamines. Monoamine neurotransmitters contain one amino group that is connected to an aromatic ring by a two-carbon chain (such as -CH2-CH2-). This structure is not present in LSD (fig. 1). A cursory Google Scholar search did not yield any relevant hits ('LSD' + 'monoamine oxidase'), loosely indicating that MAO is unlikely to be involved in LSD metabolism. However, as I suspect some self-help here - I am unsure about MAOI and LSD interactions, and I highly discourage any toying around with MAO inhibitors and any drug in general. For example, 5-HT is a typical example of an MAO substrate and LSD impinges on 5-HT2A receptors. Hence, interactions in pharmacodynamics with combined LSD and MAOI intake are likely to occur.


Fig. 1. LSD metabolites. source: Passie et al. (2008)

Reference
- Passie et al., CNS Neuroscience & Therapeutics (2008); 14: 295-314


LSD is metabolized in the liver in humans by enzymes of the Cytochrome P450 hemoprotein. The specific enzymes are CYP3A4 and CYP2D6.

CYP2D6 is generally regarded as non-inducible (meaning there appears to be no way to boost its production in humans), and can only be inhibited by other drugs that would cost more than LSD and be dangerous to take anyway.

CYP3A4 carries the answer you are looking for. It is strongly inhibited by… grapefruit! Pomegranate also has the same effect. So ingesting a lot of these fruits will make the LSD take longer to metabolize.


LSD Effects on the Body & Brain [What’s Really Occurring?]

Lysergic acid diethylamide (LSD) is a powerful hallucinogen that may cause a range of physical and psychological effects. This in-depth guide will explain what this drug is, how it affects the body and brain, and its positive and negative effects. We’ll also put some common misconceptions under the microscope to separate fact from fiction.


METHODS

Study design

The present study used a double-blind, placebo-controlled, crossover design with four experimental 6-hour test sessions to investigate responses to placebo, 5 µg LSD, 10 µg LSD, and 20 µg LSD base. Twenty-four subjects were randomly assigned to 24 possible treatment sequences, counterbalancing all treatments. The washout periods between sessions were at least 5 days. The study was registered at the Dutch Clinical Trial register (no. NTR7102 www.trialregister.nl). Additional data from this study are published elsewhere. 19

Participants

Participants were recruited from the University of Maastricht campus via advertisement, via social media, and by word of mouth. Only healthy participants who were between 18 and 40 years old, who had a body mass index between 18 and 28 kg/m 2 , and who had at least one previous experience with a hallucinogen were included in the study. The exclusion criteria were the following: pregnancy (urine pregnancy test at screening and before each test session) or lactation, a personal history of drug addiction, current or a history of psychiatric disorders or family (first-degree relative) history of major psychiatric disorders, previous experience of serious side effects to psychedelic drugs (anxiety or panic attacks), chronic or acute physical illness (based on abnormal physical exam, electrocardiogram, or hematological and chemical blood analyses or hypertension > 140/90 mmHg), tobacco smoking (> 20 cigarettes/day), excessive drinking (> 20 alcoholic consumptions per week), illicit drug use within the last 3 months, and illicit drug use during the last 7 days prior to the study or during the study. A urine drug test and alcohol breath test were performed at screening and before each test session. No illicit substances were detected during the study. The participants were not allowed to drink alcohol or xanthine-containing liquids after midnight before the study day. Previously used hallucinogens included LSD (n = 12), psilocybin (n = 19), methylenedioxymethamphetamine (MDMA)/ecstasy (n = 15), N,N-dimethyltryptamine (n = 1), ketamine (n = 1), “2C drugs” (n = 3), and salvia (n = 1).

Study procedures

The study included a screening visit and four experimental sessions (test days). Experimental sessions began at 9:00 am . An indwelling intravenous catheter was placed in an antecubital vein for blood sampling. A single oral dose of LSD or placebo was administered at 10:00 am . Autonomic and subjective drug effects were assessed repeatedly throughout the session. Test sessions ended at 4:00 pm . For the analysis of LSD concentrations in plasma, blood samples were collected in lithium heparin tubes before and 0.5, 1, 1.5, 2, 3, 4, and 6 hours after drug administration. Timepoints were selected based on existing pharmacokinetic data on LSD. 4 Blood samples were centrifuged, and plasma was frozen at − 20°C until analysis.

Study drugs

LSD (D-lysergic acid diethylamide base, high-performance liquid chromatography purity > 99% Lipomed AG, Arlesheim, Switzerland) was manufactured as an oral solution in units that contained 25 µg LSD in 1 mL of 96% ethanol. 4 Stability of the formulation for longer than the study period was documented as described elsewhere. 4 One microgram of LSD base that was used in the present study corresponded to approximately 1.23–1.33 µg of LSD tartrate (depending on the salt form and amount of crystal water), which is the form of LSD that is more likely to be used when acquired illegally (i.e., in blotter form) or was used in two recent studies that used very low doses. 15-17 However, absorption of LSD base likely takes place orally, while LSD base derived from LSD tartrate is likely absorbed when reaching the basic environment of the small intestine. To prepare doses of 5, 10, and 20 µg, 0.2, 0.4, and 0.8 mL of LSD solution, respectively, solution was diluted with ethanol (96% volume) to a final volume of 1 mL. Placebo consisted of 1 mL of ethanol (96% volume) only.

Measures

Analysis of LSD concentrations

Plasma LSD levels were analyzed by ultra-high-performance liquid chromatography tandem mass spectrometry as previously described in detail. 4 Pharmacokinetic samples with an LSD concentration below 5 pg/mL were reanalyzed by a different extraction procedure. Briefly, 150 µL aliquots of plasma were extracted with 450 µL of methanol. The samples were rigorously mixed and subsequently centrifuged. The supernatant was evaporated under a constant stream of nitrogen and resuspended in 200 µL of mobile phase A and B (10:90, volume/volume). The lower limit of quantification of 2.5 pg/mL was reached using this extraction method.

Subjective effects

Visual analog scales (VASs) were repeatedly used to assess subjective effects over time. 20-23 The VASs included separate measures for “under the influence” (any drug effect), “good drug effect,” and “bad drug effect,” and were presented as 10 cm horizontal lines (0–10), marked from “not at all” on the left to “extremely” on the right. These VASs have been shown to be sensitive and reliable measures of the effects of LSD and other psychoactive substances and suitable for pharmacokinetic-pharmacodynamic (PK-PD) analyses. 3, 4, 22, 24-26 The VASs were administered before and 0.5, 1, 1.5, 2, 3, 4, and 6 hours after LSD administration and immediately after blood sampling to provide matched measures of LSD concentrations and effects for the PK-PD modeling.

Pharmacokinetic analyses and PK-PD modeling

A noncompartmental analysis was performed prior to compartmental modeling. Peak plasma concentration (Cmax) and time to Cmax were obtained directly from the observed data. The terminal elimination rate constant (λz) was estimated by log-linear regression after semilogarithmic transformation of the data using at least three data points of the terminal linear phase of the concentration-time curve. The area under the concentration-time curve (AUC) from 0–6 hours after dosing (AUC6) was calculated using the linear up log down method. The AUC to infinity (AUC) was determined by extrapolation of the AUC6 using λz.

Pharmacokinetic parameters were estimated using compartmental modeling in Phoenix WinNonlin 6.4 (Certara, Princeton, NJ). A one-compartment model was applied with first-order input, first-order elimination, and no lag time as previously used to assess the pharmacokinetics of high doses of LSD. 4 Initial estimates for apparent volume of distribution and λ were derived from noncompartmental analyses. The model fit was not improved by a two-compartment model based on visual inspection of the plots and resulted in smaller Akaike information criterion values. The pharmacokinetic model was first fitted and evaluated. The predicted concentrations were then used as an input to the pharmacodynamic model by treating the pharmacokinetic parameters as fixed and using the classic PK/PD link model module in WinNonlin. Thus, the goal was to model the PD parameters using the PK parameters and the observed PD values. The model used a first-order equilibrium rate constant that related the observed pharmacodynamic effects of LSD to the estimated LSD concentrations at the effect site and accounted for the lag between the plasma and effect site concentration curves. 22, 27 A sigmoid maximum effect (Emax) model (EC50, Emax, γ) was selected for all pharmacodynamic effects. Half-maximal effects (EC50) and Emax estimates were taken from the PK-PD plots. 4 Lower and upper limits for Emax were set to 0 and 10, respectively, for all of the VAS scores. The sigmoidal Emax model best described the relationship between estimated effect-site concentrations and LSD effects compared with a simple Emax model (plot inspection (Figure S1) and Akaike information criteria).

Statistical analyses

The VAS score data were analyzed using repeated-measures analysis of variance, with drug dose as the within-subjects factor (four levels), followed by Tukey post hoc comparisons. Scores measured repeatedly over time are expressed as peak (Emax and/or minimum effect (Emin)) values prior to the analysis of variance (Statistica 12 software StatSoft, Tulsa, OK). The criterion for significance was P < 0.05. The time to onset, time to Cmax, time to offset, and effect duration were assessed for the model-predicted VAS “under the influence” ratings over time plots using a threshold of 25% of the maximum individual response to LSD using Phoenix WinNonlin 6.4.


Is lysergic acid diethylamide (LSD) metabolized in the body? - Biology

Lysergic acid diethylamide (LSD) is a drug used as a

Lysergic acid diethylamide (LSD) is a drug used as a Hallucinogen.

Which of the following_ statements is true?

A) Carbon dioxide diffuses from lungs into blood and oxygen diffuses from blood into lungs. B) Carbon monoxide diffuses from lungs into blood and oxygen diffuses from blood into lungs.
C) Oxygen diffuses from lungs into blood and carbon dioxide diffuses from blood into lungs. D) Oxygen diffuses from lungs into blood and carbon monoxide diffuses from blood into lungs.
A) Carbon dioxide diffuses from lungs into blood and oxygen diffuses from blood into lungs.
B) Carbon monoxide diffuses from lungs into blood and oxygen diffuses from blood into lungs.
C) Oxygen diffuses from lungs into blood and carbon dioxide diffuses from blood into lungs.
D) Oxygen diffuses from lungs into blood and carbon monoxide diffuses from blood into lungs.

Answer & Explanation Answer: C) Oxygen diffuses from lungs into blood and carbon dioxide diffuses from blood into lungs.


Myth: Acid Is the Key to Unlocking the Unconscious Mind

Many people who take LSD believe that acid unlocks your awareness of your unconscious, giving you access to repressed material from your past and revealing hidden truths about yourself and about humanity.

Truth: Taking LSD might get you thinking about things in a way you haven't thought of before, but it does not give you a key to the inner workings of your mind. Acid is just as likely to get you thinking about things that have no basis in reality as uncovering hidden truths.

And just because you have taken LSD and thought about your past, it doesn't mean you know or understand everything that has happened to you.

If you or a loved one are struggling with substance use or addiction, contact the Substance Abuse and Mental Health Services Administration (SAMHSA) National Helpline at 1-800-662-4357 for information on support and treatment facilities in your area.


When Was LSD Made Illegal?

Up until 1968, it was legal for scientists to make LSD. The drug was even marketed under the brand name Delysid, which was used by therapists to help facilitate psychoanalysis. But, the tides took a sharp turn in the late 1960s, when the first major crackdown on psychedelic drugs began. In the early 1960s, Harvard University professors Timothy Leary and Richard Alpert (a.k.a. Ram Dass) ran a series of famous experiments with students, including undergrads. The effects of both LSD and psilocybin mushrooms were put to the test. But, the professors’ studies were heavily scrutinized by the scientific community Leary and Alpert conducted the experiments while also tripping themselves and encouraging recreational use.

In 1963, both Leary and Alpert were fired from Harvard University. By 1966, Sandoz stopped producing and distributing LSD, due to growing concerns about the safety and the popularity of LSD as a recreational drug. But, that didn’t stop a media frenzy following the plight of Leary and the controversies surrounding LSD. Leary applauded acid for its safety and spiritual power. In a 1966 senate subcommittee hearing, he explained that LSD has the “eerie power to release ancient energies from the brain, I would say even sacred energies.” But, moral skeptics worried that Leary’s perspective on LSD would encourage young people to turn on, tune in, and “drop out.”

Leary’s work and activism came under fire again and again in the mid-1960s. By 1966, he was included in a series of senate hearings on the drug. Although Leary was adamant that LSD was safe and had value to mental and spiritual health, he was countered by Dr. Sidney Cohen, another prominent psychedelic researcher. In Cohen’s perspective, LSD was safe only when used in an appropriate medical setting and heavily discouraged recreational use.

In 1968, the US officially criminalized the production, possession, and distribution of LSD. By 1970, LSD was as listed as a schedule 1 drug—a substance with no medical value—by the Comprehensive Drug Abuse Prevention and Control Act. Thus, the War on Drugs began. LSD laboratories were forced underground.


Metabolism of Lysergic Acid Diethylamide

IN a communication on lysergic acid diethylamide, Axelrod, Brady, Witkop and Evarts 1 state: “Although the hallucinogenic agent, lysergic acid diethylamide, has been the subject of numerous investigations, little is known about its biological fate”. However, a number of facts, not mentioned in this communication, about the destruction, distribution and excretion of this compound have recently been published which show that we are not quite as ignorant about the biological fate of this compound as one might infer from this statement.


Abstract

Lysergic acid diethylamide (LSD) is one of the most potent psychoactive agents known, producing dramatic alterations of consciousness after submilligram (≥20 μg) oral doses. Following the accidental discovery of its potent psychoactive effects in 1943, it was supplied by Sandoz Laboratories as an experimental drug that might be useful as an adjunct for psychotherapy, or to give psychiatrists insight into the mental processes in their patients. The finding of serotonin in the mammalian brain in 1953, and its structural resemblance to LSD, quickly led to ideas that serotonin in the brain might be involved in mental disorders, initiating rapid research interest in the neurochemistry of serotonin. LSD proved to be physiologically very safe and nonaddictive, with a very low incidence of adverse events when used in controlled experiments. Widely hailed by psychiatry as a breakthrough in the 1950s and early 1960s, clinical research with LSD ended by about 1970, when it was formally placed into Schedule 1 of the Controlled Substances Act of 1970 following its growing popularity as a recreational drug. Within the past 5 years, clinical research with LSD has begun in Europe, but there has been none in the United States. LSD is proving to be a powerful tool to help understand brain dynamics when combined with modern brain imaging methods. It remains to be seen whether therapeutic value for LSD can be confirmed in controlled clinical trials, but promising results have been obtained in small pilot trials of depression, anxiety, and addictions using psilocybin, a related psychedelic molecule.


How Long Does it take LSD to kick in?

Lysergic acid diethylamide (LSD), or acid, lasts up to 12 hours Trusted Source in the body and is metabolized within 48 hours.

When you take it orally, it’s absorbed by your gastrointestinal system and channeled into your bloodstream. From there, it travels to your brain and other organs.

It only stays in your brain for about 20 minutes, but the effects can last considerably longer depending how much is in your blood.

Healthline does not endorse the use of any illegal substances, and we recognize abstaining from them is always the safest approach. However, we believe in providing accessible and accurate information to reduce the harm that can occur when using.

People typically begin to feel the effects of acid within 20 to 90 minutes. The effects peak after around 2 to 3 hours, but this can vary significantly from person to person.

How long acid takes to kick in and how intense the effects are depend on several factors, including:

An acid trip can last anywhere from 6 to 15 hours. Some lingering effects, referred to as “afterglow,” can last for another 6 hours after that. If you count the comedown, you could be looking at 24 hours before your body returns to its normal state.

As for the actual effects, they can include:

The same factors that influence how long acid takes to kick in also influence how long the effects linger. The intensity and duration can also be affected by over-the-counter or prescription medications.

Compared to other drugs, acid can be harder to detect because it’s quickly broken down in the liver. And since only a small amount is needed to get the desired effect, most people only ingest small amounts.

The specifics of how long it’s detectable depends on the type of drug test used:

  • Urine. Acid is quickly transformed into inactive compounds by your liver, leaving about 1 percent of unchanged LSD in your urine. Most routine drug tests are urine tests and can’t detect LSD.
  • Blood. In a 2017 study, LSD was detectable in blood samples 16 hours after participants had been given 200 micrograms of the drug. For participants given a dose half that size, LSD was detectable 8 hours after administration.
  • Hair.Hair follicle drug tests are useful for detecting past drug use and can detect a number of drugs up to 90 days after its use. But when it comes to LSD, there’s not enough data to say how reliably a hair follicle test can detect it.

There are several things that can affect how long acid is detectable in a drug test.

  • Your body composition. Your height and amount of body fat and muscle plays a role in how long acid is detectable. The more fat cells a person has, the longer drug metabolites linger in the body. Body water content also matters. The more you have, the faster the drug is diluted.
  • Your age. Your liver function and metabolism slows with age. Younger people metabolize acid faster than older adults.
  • Your liver function. Your liver plays a key role in metabolizing acid. If you have a medical condition or take a medication that impairs your liver function, LSD will be harder to eliminate.
  • Time between use and testing. Acid is eliminated from the body quickly, which makes it hard to detect. The sooner the drug test is performed after acid is taken, the more likely it is to detect it.
  • How much you take. The more you take, the longer it will be detectable. How often you take it can also affect detection time.
  • Your metabolism. The faster your metabolism, the faster acid leaves your system.

Acid is eliminated from your system quickly, but if you want to try to speed up the process, there are things you can do.

  • Hydrate. Acid and its metabolites are excreted through your urine. Staying hydrated before, during, and after taking acid can help get it out of your system faster.
  • Stop taking acid. Timing matters when it comes to testing for LSD, and the sooner you stop taking it before a drug test, the less likely it will be detectable.
  • Exercise. It’s not the quickest fix, but exercise can boost your metabolism. A combination of aerobic exercise and lifting weights has the most impact on metabolism.

Considering trying acid? There are a couple of big things to know before taking the leap.

Risks

Some people who use LSD report having bad trips and lasting emotional effects. There’s no surefire way to know whether your trip will be good or bad, but your risk of experiencing longer-lasting effects, such as flashbacks, increases when you take a high dose or use it often.

Using LSD frequently or in large amounts also increases your risk of developing a tolerance or psychological addiction to it. It can also increase your risk of a rare condition called hallucinogen persistent perception disorder.

Keep in mind that LSD can have extremely powerful effects that can alter your perception and judgement. This might make you more likely to take risks or do things you otherwise wouldn’t.

Safety tips

If you’re going to try LSD, there are a few things you can do to make it less risky:


Types of LSD Drug Tests

There are various types of tests that could be utilized to detect the presence of LSD. Standard drug tests will not test for the presence of LSD, and in most cases, neither will extensive drug tests. In the past, LSD was tested for among those in the military, but it has since been removed from their testing protocol due to the fact that testing for LSD is expensive. That said, if you want to test yourself to determine whether LSD is out of your system, it is a possibility.

Urine tests: The most common way to determine whether someone has used LSD is to test their urine for LSD and LSD metabolites. Not only is urine-based testing fairly expensive, but it is not common. Furthermore, LSD is not similar in chemical structure to other drugs being tested for on standard urine tests – and therefore will not trigger false-positive for another drug.

Since the metabolite 2-oxo-3-hydroxy LSD has a longer half life than LSD, and is only detectable in urine, this is the substance that will be assessed in urine samples. LSD and 2-oxo-3-hydroxy LSD are detectable in urine as soon as 3 hours after ingestion, and can remain detectable for up to 3 days post-ingestion. It would be highly unlikely that the 2-oxo-3-hydroxy LSD metabolite would remain in your system for over 3 days post-ingestion this would require an extremely large (toxic) dosage.

Blood tests: Another way to determine whether someone has ingested LSD is to collect a blood sample. It is thought that LSD could be detected in a blood sample as soon as 3 hours and up to 12 hours post-ingestion. A test known as a radioimmunoassay (RIA) can be used to pinpoint the contents of LSD down to a level of 0.5 ng/ml.

Additionally, another test called an enzyme-linked immunosorbent assay (ELISA) could be used for more advanced detection, pinpointing levels down to 1 pg per 25 microliters of blood. In other words, if you wanted to pinpoint whether someone had likely used LSD and how much was likely in their system, an ELISA would provide the most accurate results.

Other ways to determine whether LSD is still in your system include: HPTLC (high-performance thin layer chromatography) and gas chromatography/mass spectrometry (GC/MS). Detection limits are thought to be set at 0.1 ng/ml and 0.25 ng/ml for its metabolites.

Hair tests: The testing of hair for the presence of LSD and its metabolites is extremely uncommon. If you are subject to a hair test, follicles are typically extracted from the top of your head between 3 cm and 6 cm. Assuming the hair is properly extracted and analyzed with gas chromatography/mass spectrometry (GC/MS) or HPLC (high-performance liquid chromatography), the presence of LSD can be detected.

Since most drugs can be detected up to 90 days (3 months) after ingestion on a hair test, it should be thought that LSD has a similar window of detection. Hair tests are advantageous in that they can determine whether an individual has ingested LSD over a longer-term than urine or blood tests. That said, the techniques utilized for a hair test are often time consuming, costly, and require advanced medical equipment – rendering them unfeasible outside of scientific research.

Are people still tested for LSD these days?

Despite the fact that it is possible to test people for the presence of LSD, most drug tests do not seek to determine whether an individual had ingested LSD. Primarily this is due to the fact that LSD tests are expensive (requiring advanced equipment) and based on the finding that there are relatively few LSD users. As a result, the costs associated with testing for LSD outweigh the benefits.

  • Businesses / Schools: It is thought that certain businesses and/or schools may test current and prospective employees/students for the presence of LSD. In addition, some schools may require that athletes receive advanced drug testing (such as for LSD). That said, testing for LSD by businesses and schools is usually uncommon.
  • Military: In the 2000s, the military initially tested for LSD. However, as of 2008, testing for LSD was thought to be discontinued as of 2011 based on the finding that a negligible number of personnel tested positive after 3 years. It is thought that the military still may conduct intermittent/random LSD tests, but these tests aren’t usually a part of standard drug screenings.
  • Rehabilitation clinics: Some rehabilitation facilities may test clients for the presence of all illicit drugs, including LSD. These clinics may mandate an advanced drug testing panel to ensure that their clients have remained sober from all substances during the rehab process.
  • Self-testing: If you want to know (out of curiosity) whether LSD (and its metabolites) are likely cleared from your system, you could test yourself. These days LSD test kits can be purchased on Amazon to determine how much of the drug (and its metabolites) remain in your system.

Tips to get LSD out of your system quickly

If you are looking to enhance your body’s ability to clear exogenous substances like LSD, you may want to consider some of the tips listed below. Understand that these tips may be more effective for certain individuals than others.

  1. Stop using: Assuming you want your body fully clear of LSD and its metabolites, you’ll need to stop using the drug for at least 5 days. After 5 days, you can be pretty sure that it has been completely eliminated from your system. Realize that if you continue ingesting LSD (even at low doses), it will take longer for the drug to be fully cleared from your body.
  2. Diet / hydration: Eating food along with LSD may help your body process the drug and excrete it at a quicker rate. In addition, maintaining proper hydration is necessary if you want to ensure the fastest possible metabolism of LSD and elimination of its metabolites. Metabolites of LSD are eliminated via urinary excretion drinking enough water can help flush it out.
  3. Manipulate pH: It is known that individuals with a highly alkaline pH may retain drugs (and metabolites) for longer than those with a highly acidic pH. If you want to ensure that LSD is being eliminated quickly and isn’t getting reabsorbed into your system, consider taking steps to increase the acidity of your pH.
  4. Drugs / supplements: Taking certain drugs and/or supplements may act as “inducers” within the liver, speeding up the metabolism (and ultimately elimination) of LSD. Obviously you’ll want to make sure that none of these substances have contraindications with LSD prior to ingestion. That said, they could make a subtle difference if you are concerned about speeding up clearance.
  5. Exercise: Getting daily exercise helps improve blood flow throughout the body and improves health. Daily exercise also helps speed up metabolism and the functioning of organs such as your liver – which is responsible for metabolizing LSD. While the thought of going for a jog may not be too appealing after a “trip,” it could help ensure that the drug clears from your system as soon as possible.

How long do you believe LSD stays in your system?

If you’ve taken LSD, how long do you believe it stayed in your system? To help others get a better idea of your experience, mention the dosage you took, whether you simultaneously ingested other drugs, whether it was taken on an empty stomach, etc. Furthermore, if you were drug-tested for LSD, discuss the results of the test below.

Understand that a majority of LSD users will have fully excreted the drug and metabolites within a 24 to 48 hour window. There’s no reason to think that the drug stays in your system for a longer period of time. Additionally, there’s no significant evidence to support the myth that LSD remains permanently stored within a person’s spine.

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